The Istanbul meeting follows Foreign Minister Abbas Araghchi's warning of "irreversible" consequences if the European powers move to reimpose United Nations sanctions on Iran that were lifted under a 2015 deal.
The so-called E3 were parties to that agreement along with China, Russia and the United States.
But Trump effectively torpedoed the deal during his first term in 2018, by unilaterally abandoning it and reimposing sanctions on Iran's banking sector and oil exports.
A year later, Iran responded by rolling back its own commitments under the deal, which provided relief from sanctions in return for UN-monitored restrictions on Iran's nuclear activities, reports BSS.
The three European powers have been weighing whether to trigger the 2015 deal's "snapback" mechanism, which would reinstate UN sanctions in response to Iranian non-compliance -- an option that expires in October.
Such a stance "risks provoking a global nuclear proliferation crisis that would primarily affect Europeans themselves, Iran's top diplomat warned.
However, writing in the French weekly Le Point, he also noted that Tehran was "ready to turn the page" in its relations with Europe.
Friday's meeting with the European powers comes less than a week after a fourth round of Iran-US nuclear talks which Tehran called "difficult but useful", and after which a US official said Washington was "encouraged".
Araghchi said Friday's talks will be at deputy foreign ministers level.
- 'Getting close' -
Speaking on a visit to Qatar Thursday, Trump said the United States was "getting close" to a deal with Iran that would avert military action.
"We're not going to be making any nuclear dust in Iran," he said.
The Oman-mediated Iran-US talks were the highest-level contact between the two foes since Washington abandoned the nuclear accord in 2018.
Since returning to office, Trump has revived his "maximum pressure" policy on Tehran, backing nuclear diplomacy but warning of military action if it fails.
On Thursday, US news website Axios reported that the Trump administration had given Iran a "written proposal" for a deal during the fourth round of talks on Sunday.
Araghchi denied the report, saying "we have not been given anything".
He added however that "we are ready to build trust and transparency about our nuclear programme in response to the lifting of sanctions."
Trump has said he presented Iran's leadership with an "olive branch", adding that it was an offer that would not last for ever.
He further threatened to impose "massive maximum pressure", including driving Iranian oil exports to zero if talks failed.
Iran currently enriches uranium to 60 percent, far above the 3.67 percent limit set in the 2015 deal but below the 90 percent needed for a nuclear warhead.
Tehran insists its right to continue enriching uranium for peaceful purposes is "non-negotiable" but says it would be open to temporary restrictions on how much uranium it enriches and to what level.
On Wednesday, Iran's atomic energy agency chief Mohammad Eslami reiterated that Tehran "does not seek nuclear militarisation", adding that enrichment was under the supervision of the UN nuclear watchdog.
"The dismantling of enrichment is not accepted by Iran," he stressed.